There are only a few people in this world who are diagnosed with these conditions. The circumstances surrounding such rare diseases and strange medical conditions are unknown. Here we have compiled 20 such conditions that are known to mankind.

1. Ehlers-Danlos Syndrome

Ehlers-Danlos Syndrome is a collection of heritable connective tissue disorders. It is thought to alter the biology of collagen in the body which can lead to multi-systemic symptoms. Physical characteristics such as any of the following are common: soft, stretchy, saggy or too thin skin, easy bruising, easy wounding, poor wound healing and/or atrophic scarring. It is often extremely painful and in some cases can be life-threatening.

2.Flesh-Eating Bacteria (also called Necrotizing Fasciitis)

Photo Credit: Ilaria Tocco, MD, Luca Lancerotto, MD, Alex Pontini, MD, Anna Voltan, MD, Bruno Azzena, MD, “Synchronous” Multifocal Necrotizing Fasciitis, The Journal of Emergency Medicine

3. Dermatographia

Dermatographia is a condition also known as skin writing. When people with this condition lightly scratch their skin, the scratches redden into a raised wheal similar to hives. The marks disappear within 30 minutes. Though the cause for this condition is unknown, infections or allergic reactions to certain medicines such as penicillin can trigger this.

4.Alice in Wonderland Syndrome

Named in a 1955 Canadian Medical Association Journal(CMAJ) article, this syndrome is often associated with people who have migraine headaches and epilepsy. People with the condition may have distorted vision or perceptions that make it seem like parts of their body are much bigger or smaller than expected, or that one body part is taller or shorter than they are in reality.

3. Real life Smurf – Blue man Syndrome

Paul Karason, 62, became internet famous when his skin turned permanently blue after years of self-medication. Popularly known as ‘Papa Smurf’, Karason started turning blue after he tried treating a skin condition on his face with a silver preparation. He’s also been drinking colloidal silver, which is silver in a liquid suspension, for about 14 years, he says.

4. Synesthesia – joined perception

Synesthesia is a condition in which one sense is simultaneously perceived as if by one or more additional senses. There are synesthetes who hear sounds in response to smell, who smell in response to touch, or who feel something in response to sight. Any such combination of these senses are possible. There are rare cases where some people who possess synesthesia have three or even more senses.

5. Stone Man’s Disease (also called Fibrodysplasia Ossificans Progressiva)

Stone man’s disease is a disorder of the connective tissue where ligaments, tendons or skeletal muscles essentially turn into bone.The first symptom of this disorder that people usually develop is irregular big toes, which can occur at birth, according to the National Organization for Rare Disorders. Over time, FOP progresses, usually from the neck and shoulders downward, according to the U.S. National Library of Medicine. In people who have the disease, injuries to muscles or certain illnesses can trigger swelling and inflammation, which may then cause more tissues to turn to bone.

6. Tinnitus – a constant ringing sound in his/her ears.

If you experience a ringing sound in your ears that no one else can hear, you may have tinnitus, an audiological and neurological condition experienced by nearly 50 million Americans. The ringing sound could be coming from one or both ears and in some cases, sufferers can even hear music or unclear voices in their head.

7. Alien Hand Syndrome

Alien hand syndrome (AHS) is characterized by involuntary movements of a limb, usually the hand, that seem purposeful or functional. People with this movement disorder may also feel that the limb is not a part of their body.

Authors of a meta-analysis of research on AHS published in Tremor and Other Hyperkinetic Movements wrote, “Sometimes the limb is personified: patients have named their alien hands.” Common causes of AHS include strokes, brain tumors and neurodegenerative illness. Treatments may involve Botox injections (which may temporarily weaken the muscles), cognitive behavioral therapy and distracting the affected hand by having it hold an object. As seen in the movie “Dr. Strangelove,” there have been reports of people with this syndrome hitting or attempting to choke themselves.

8. Sleeping Beauty Syndrome

Just like the long-unconscious princess, people with the neurological condition called Sleeping Beauty Syndrome experience periods of excessive sleep.

These episodes of lengthy sleep may be proceeded by flu-like symptoms and, when they’re awake, people with this syndrome may exhibit various odd behaviors, including eating excessively, hallucinating or acting childishly.

But unlike the princess that the name conjures, 70 percent of the people who have this disorder are adolescent males, according to the NINDS. Stimulant medications are used to treat Kleine-Levin syndrome, and episodes tend to subside as a person reaches adulthood.

9. Trimethylaminuria – Fish odor syndrome.

When the body is unable to break down certain nitrogen-containing compounds such as trimethylamine (TMA), Trimethylaminuria is formed . The TMA accumulated in the body is then released via urine, sweat, and breath. Mostly found in women, this disorder has no cure and makes the person smell like a fish.

10.  Tree man syndrome

Tree-Man” Disease, which is an immune deficiency. It is believed to stem from a genetic defect and is a failed human response to the Human Papillomavirus (HPV)

It is not contagious and doctors who often treat it freely touch the person who has it.

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